L-Citrulline vs. L-Arginine: Maximizing Cerebral Microvascular Flow

While L-arginine directly donates nitrogen atoms to endothelial nitric oxide synthase (eNOS), oral arginine is heavily metabolized in the gut and liver. L-citrulline bypasses first-pass hepatic metabolism completely, converting systemically in vascular endothelial tissue into sustained L-arginine.

Synergistic Dual Delivery

By compounding 250 mg L-citrulline with 200 mg L-arginine, VapoCept establishes both rapid morning eNOS substrate availability and sustained plasma arginine retention, promoting hours of continuous microcapillary cerebral dilation.